Gap19 acetate(1507930-57-5,free)
CAS No. 1507930-57-5
Gap19 acetate(1507930-57-5,free) ( —— )
产品货号. M22965 CAS No. 1507930-57-5
Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.Hemichannel inhibition is due to the binding of Gap19 to the C-terminus (CT) thereby preventing intramolecular CT-CL interactions.?The peptide inhibited Cx43 hemichannel unitary currents in both HeLa cells exogenously expressing Cx43 and acutely isolated pig ventricular cardiomyocytes.?
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥616 | 有现货 |
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5MG | ¥1013 | 有现货 |
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10MG | ¥1580 | 有现货 |
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25MG | ¥3054 | 有现货 |
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50MG | ¥4471 | 有现货 |
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100MG | ¥6375 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Gap19 acetate(1507930-57-5,free)
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.Hemichannel inhibition is due to the binding of Gap19 to the C-terminus (CT) thereby preventing intramolecular CT-CL interactions.?The peptide inhibited Cx43 hemichannel unitary currents in both HeLa cells exogenously expressing Cx43 and acutely isolated pig ventricular cardiomyocytes.?
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产品描述Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.Hemichannel inhibition is due to the binding of Gap19 to the C-terminus (CT) thereby preventing intramolecular CT-CL interactions.?The peptide inhibited Cx43 hemichannel unitary currents in both HeLa cells exogenously expressing Cx43 and acutely isolated pig ventricular cardiomyocytes.?Treatment with Gap19 prevented metabolic inhibition-enhanced hemichannel openings, protected cardiomyocytes against volume overload and cell death following ischemia/reperfusion in vitro and modestly decreased the infarct size after myocardial ischemia/reperfusion in mice in vivo.?
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同义词——
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通路Others
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靶点Other Targets
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受体Cx43
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研究领域——
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适应症——
化学信息
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CAS Number1507930-57-5
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分子量1161.44
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分子式C55H96N14O13
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纯度>98% (HPLC)
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溶解度——
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SMILESCC[C@]([H])(C)[C@@]([H])(/C(O)=N/[C@@]([H])(CCCCN)/C(O)=N/[C@@]([H])(CCCCN)/C(O)=N/[C@@]([H])(CC1=CC=CC=C1)/C(O)=N/[C@@]([H])(CCCCN)C(O)=O)/N=C([C@]([H])(CCC(O)=O)/N=C([C@]([H])([C@@]([H])(C)CC)/N=C([C@]([H])(CCC(O)=N)/N=C([C@]([H])(CCCCN)N)\O)\O)\O)\O.CC(O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Boengler K, et al. Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 2013 Jun 6;4:73.
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