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首页- Products - Others - Other Targets - Gap19 acetate(1507930-57-5,free)

Gap19 acetate(1507930-57-5,free)

CAS No. 1507930-57-5

Gap19 acetate(1507930-57-5,free) ( —— )

产品货号. M22965 CAS No. 1507930-57-5

Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.Hemichannel inhibition is due to the binding of Gap19 to the C-terminus (CT) thereby preventing intramolecular CT-CL interactions.?The peptide inhibited Cx43 hemichannel unitary currents in both HeLa cells exogenously expressing Cx43 and acutely isolated pig ventricular cardiomyocytes.?

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥616 有现货
5MG ¥1013 有现货
10MG ¥1580 有现货
25MG ¥3054 有现货
50MG ¥4471 有现货
100MG ¥6375 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Gap19 acetate(1507930-57-5,free)
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.Hemichannel inhibition is due to the binding of Gap19 to the C-terminus (CT) thereby preventing intramolecular CT-CL interactions.?The peptide inhibited Cx43 hemichannel unitary currents in both HeLa cells exogenously expressing Cx43 and acutely isolated pig ventricular cardiomyocytes.?
  • 产品描述
    Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.Hemichannel inhibition is due to the binding of Gap19 to the C-terminus (CT) thereby preventing intramolecular CT-CL interactions.?The peptide inhibited Cx43 hemichannel unitary currents in both HeLa cells exogenously expressing Cx43 and acutely isolated pig ventricular cardiomyocytes.?Treatment with Gap19 prevented metabolic inhibition-enhanced hemichannel openings, protected cardiomyocytes against volume overload and cell death following ischemia/reperfusion in vitro and modestly decreased the infarct size after myocardial ischemia/reperfusion in mice in vivo.?
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Cx43
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1507930-57-5
  • 分子量
    1161.44
  • 分子式
    C55H96N14O13
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    CC[C@]([H])(C)[C@@]([H])(/C(O)=N/[C@@]([H])(CCCCN)/C(O)=N/[C@@]([H])(CCCCN)/C(O)=N/[C@@]([H])(CC1=CC=CC=C1)/C(O)=N/[C@@]([H])(CCCCN)C(O)=O)/N=C([C@]([H])(CCC(O)=O)/N=C([C@]([H])([C@@]([H])(C)CC)/N=C([C@]([H])(CCC(O)=N)/N=C([C@]([H])(CCCCN)N)\O)\O)\O)\O.CC(O)=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Boengler K, et al. Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 2013 Jun 6;4:73.
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